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Effect of biochar amendment on soil’s retention capacity for estrogenic hormones from poultry manure treatment

Sukhjot MANN, Zhiming QI, Shiv O. PRASHER, Lanhai LI, Dongwei GUI, Qianjing JIANG

《农业科学与工程前沿（英文）》 2017年 第4卷 第2期   页码 208-219 doi: 10.15302/J-FASE-2017138

摘要： Most animals, including humans, produce natural sex hormones such as estrogens: 17β-estradiol (E2) and estrone (E1). These compounds are able to disrupt the reproductive systems of living organisms at trace concentrations (ng·L ). This experiment tests the hypothesis that 1% slow pyrolysis biochar-amended sandy soil could retain significant amount of estrogens (E1, E2) from poultry manure in its second year of application. The experiment was conducted over 46 days and consisted of a series of lysimeters containing sandy soil with biochar-amended topsoil. The application rate of poultry manure was kept at 2.47 kg·m . The biochar held a significant concentration of hormone during the first year of its application. However, in the following year (current study), there was no significant retention of hormones in the biochar-amended soil. During the first year after application, the biochar was fresh, so its pores were available for hydrophobic interactions and held significant concentration of hormones. As time passed there were several biotic and abiotic changes on the surface of the biochar so that after some physical fragmentation, pores on the surface were no longer available for hydrophobic interactions. The biochar started releasing dissolved organic carbon, which facilitated greater mobility of hormones from poultry manure down the soil profile.

关键词： adsorption     degradation     dissolved organic carbon     17β-estradiol (E2)     estrone (E1)    

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Removal of 17β-estradiol in laccase catalyzed treatment processes

XIA Qing,KONG Deyang,LIU Guoqiang,HUANG Qingguo,ALALEWI Aamr,LU Junhe

《环境科学与工程前沿（英文）》 2014年 第8卷 第3期   页码 372-378 doi: 10.1007/s11783-013-0567-3

摘要： The removal of 17β-estradiol (E2) in laccase catalyzed oxidative coupling processes was systematically studied in this work. We focused on the influence of pH and natural organic matter (NOM) on the performance of the enzymatic treatment processes. It was found that the optimal pH for E2 removal was between 4 and 6. The removal of E2 was slightly inhibited in the presence of NOM. Enzymatic transformation of E2 was second-order in kinetics with first-order to both the concentrations of the enzyme and contaminant. Mass spectrum (MS) analysis suggested that coupling products were formed through radical-radical coupling mechanism. The results of this study demonstrated that laccase catalyzed oxidative coupling process could potentially serve as a treatment strategy to control steroid estrogens.

关键词： 17β-estradiol     laccase     oxidative coupling processes     kinetics     mechanisms    

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Primary hypertrophic osteoarthropathy: an update

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 60-64 doi: 10.1007/s11684-013-0246-6

摘要：

Digital clubbing, which has been recognized as a sign of systemic disease, is one of the most ancient diseases. However, the pathogenesis of clubbing and hypertrophic osteoarthropathy has hitherto been poorly understood. The study of a clinically indistinguishable idiopathic form (primary hypertrophic osteoarthropathy, PHO) provides an opportunity to understand the pathogenesis of hypertrophic osteoarthropathy. Current advances in the study of PHO are discussed. The impaired metabolism of prostaglandin E2 (PGE2) plays a central role in its pathogenesis.

关键词： digital clubbing     primary hypertrophic osteoarthropathy     prostaglandin E2 (PGE2)    

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17–26.5 GHz 42.5 dBm宽带高效率GaN功率放大器设计 Correspondences

黎明1,2,李智群1,3,郑权2,蔺兰峰2,陶洪琪2

《信息与电子工程前沿（英文）》 2022年 第23卷 第2期   页码 346-350 doi: 10.1631/FITEE.2000513

摘要： 该功率放大器采用0.15 μm栅长GaN-HEMT工艺，其工作频段可以覆盖整个K频段，即17–26.5 GHz。该功率放大器采用三级放大拓扑结构，在连续波条件下，测试结果表明，在17–26.5 GHz频带范围内饱和输出功率超过42.5 dBm，平均PAE为30%，在19.8 GHz时PAE达到最大，为32.1%，

关键词： K波段；高效率；宽带；氮化镓（GaN）；功率放大器    

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Th17 Cells in autoimmune diseases

null

《医学前沿（英文）》 2015年 第9卷 第1期   页码 10-19 doi: 10.1007/s11684-015-0388-9

摘要：

Th17 cells are a new subset of CD4+ T cells involved in the clearance of extracellular pathogens and fungi. Accumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in the pathogenesis of multiple autoimmune-mediated inflammatory diseases. Here, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmune diseases. We also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic application to treat human autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sj?gren’s syndrome, inflammatory bowel disease, and multiple sclerosis.

关键词： IL-17     Th17 cells     RORγt     autoimmune diseases     posttranslational modification     inhibitors    

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Relationship between Th17 cells and allograft rejection

Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 491-494 doi: 10.1007/s11684-009-0066-x

摘要： Thl7 cells, a special kind of auxiliary type T cells, can secrete IL-17A, IL-17F, IL-21, IL-22, etc., as a newly discovered T-cell subset in recent years. As a different subset from the Thl and Th2 cells, Th17 cells play an important role in the development of a variety of autoimmune diseases. A current study shows that the IL-6 inflammatory response of the organization in combination with the occurrence of TGF-β can induce the differentiation of Thl7 cells. IL-23 can promote the production of IL17, as well as participate in amplification and maintenance of the survival of IL-l7 generating cells. In this process, STAT3 and ROR-γt are key transcription factors for the growing of Thl7 cells. As our knowledge on Th17 family members is rapidly growing and changing, it will be important to specify their involvement in the induction and regulation of allograft rejection in animal models as well as in clinical settings. Herein, we review the key features of Th17 cells and discuss their potential relevance to transplantation immunity.

关键词： TH17 cells     regulation     allograft     rejection    

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sources of dissolved organic matter from wastewater treatment plants and their mediation effect on 17α-ethinylestradiol

《环境科学与工程前沿（英文）》 2023年 第17卷 第6期 doi: 10.1007/s11783-023-1669-1

摘要：

● EE2 photodegradation behavior in the presence of four WWTPs’ DOM was explored.

关键词： Photosensitivity sources     17α-ethinylestradiol     Photodegradation     Dissolved organic matter     Wastewater treatment plants    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

null

《医学前沿（英文）》 2016年 第10卷 第1期   页码 76-84 doi: 10.1007/s11684-015-0426-7

摘要：

Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome (APS). However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti-β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex. The interaction between the anti-β2GP I /β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GP I /β2GP I complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2' inhibitor. Results showed that the anti-β2GP I /β2GP I complex induced platelet activation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency in APS patients.

关键词： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th

Michela CIGOLA,Yibing FANG

《机械工程前沿（英文）》 2016年 第11卷 第1期   页码 3-11 doi: 10.1007/s11465-015-0359-5

摘要：

This study aims to investigate the role played by Xu Guangqi (1562–1633), minister of the Ming Dynasty, in the development of European scientific and technical knowledge in China between the 16th and 17th centuries by analyzing a book of Western technology that he wrote, namely, Taixi Shuifa (On Western Hydraulics). Several Western books related to machine knowledge are searched to trace the source of the illustrations in Taixi Shuifa. We found that Archimedes’ screw and Ctesibius’ machine, which are included in Vitruvius’ De Architectura volumes, also appear in the work of Xu Guangqi.

关键词： Vitruvius’ De Architectura     Xu Guangqi’s Taixi Shuifa     Jesuit missionaries     Italian Renaissance     drawing     representation    

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Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

《医学前沿（英文）》 2019年 第13卷 第1期   页码 104-111 doi: 10.1007/s11684-017-0568-x

摘要： Mitochondrion-localized retinol dehydrogenase 13 (Rdh13) is a short-chain dehydrogenase/reductase involved in vitamin A metabolism in both humans and mice. We previously generated knockout mice and showed that Rdh13 deficiency causes severe acute retinal light damage. In this study, considering that Rdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injury induced by carbon tetrachloride (CCl ). Although Rdh13 deficiency showed no significant effect on liver histology and physiological functions under regular culture, the mice displayed an attenuated response to CCl -induced liver injury. Their livers also exhibited less histological changes and contained lower levels of liver-related metabolism enzymes compared with the livers of wild-type (WT) mice. Furthermore, the mice had Rdh13 deficiency and thus their liver cells were protected from apoptosis, and the quantity of their proliferative cells became lower than that in WT after CCl exposure. The ablation of gene decreased the expression levels of thyroid hormone-inducible nuclear protein 14 (Spot14) and cytochrome P450 (Cyp2e1) in the liver, especially after CCl treatment for 48 h. These data suggested that the alleviated liver damage induced by CCl in mice was caused by Cyp2e1 enzymes, which promoted reductive CCl metabolism by altering the status of thyroxine metabolism. This result further implicated Rdh13 as a potential drug target in preventing chemically induced liver injury.

关键词： retinol dehydrogenase 13     carbon tetrachloride     acute liver injury     Cyp2e1     Spot14    

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Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

Guizhen Wang, Qun Zhao, Hui Zhang, Fan Liang, Chen Zhang, Jun Wang, Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou

《医学前沿（英文）》 2021年 第15卷 第2期   页码 252-263 doi: 10.1007/s11684-021-0837-6

摘要： An unexpected observation among the COVID-19 pandemic is that smokers constituted only 1.4%−18.5% of hospitalized adults, calling for an urgent investigation to determine the role of smoking in SARS-CoV-2 infection. Here, we show that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase mRNA but trigger ACE2 protein catabolism. BaP induces an aryl hydrocarbon receptor (AhR)-dependent upregulation of the ubiquitin E3 ligase Skp2 for ACE2 ubiquitination. ACE2 in lung tissues of non-smokers is higher than in smokers, consistent with the findings that tobacco carcinogens downregulate ACE2 in mice. Tobacco carcinogens inhibit SARS-CoV-2 spike protein pseudovirions infection of the cells. Given that tobacco smoke accounts for 8 million deaths including 2.1 million cancer deaths annually and Skp2 is an oncoprotein, tobacco use should not be recommended and cessation plan should be prepared for smokers in COVID-19 pandemic.

关键词： SARS-CoV-2     tobacco smoke     benzo(a)pyrene     ACE2     Skp2    

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基于实时CT扫描技术的CO2和N2交替注入条件下煤吸附膨胀和解吸收缩规律研究 Article

Ranjith, Herbert E. Huppert

《工程（英文）》 2022年 第18卷 第11期   页码 88-95 doi: 10.1016/j.eng.2022.03.010

摘要：

深部煤层是分布最广泛的适宜二氧化碳（CO2）地质封存的地层之一，且通常位于大型CO2排放源附近。将CO2注入到煤层中具有巨大的CO2封存潜力，同时可以提高煤层气的采收率（CO2-ECBM）。本文采用原位同步辐射X射线显微CT扫描技术，首次在原位条件下直接证明了注入氮气（N2）可以置换解吸CO2并减小因CO2吸附引起的煤基质膨胀研究结果表明，煤层中注入经过简单处理的烟道气（主要成分为N2和CO2），是技术上可行的CO2-ECBM 替代方案。其次，N2的存在可以使煤层保持较高的渗透率，实现长期CO2注入封存和煤层气增产。

关键词： CCS     CO2-ECBM     碳中和     X 射线成像     煤渗透率    

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利用cyp17a1缺失的伪雄鲤成功构建全雌鲤群体 Article

翟刚, 舒婷婷, 陈贶新, 娄气永, 贾景怡, 黄建飞, 石闯 , 金霞, 贺江燕, 姜冬火, 钱雪桥, 胡炜, 殷战

《工程（英文）》 2022年 第8卷 第1期   页码 181-189 doi: 10.1016/j.eng.2021.03.026

摘要： 本研究针对雌鲤生长快于雄鲤的两性生长异形的特性，以cyp17a1 为靶点进行了CRISPR/Cas9介导的基因编辑操作，利用cyp17a1 敲除后形成的伪雄鲤，成功构建了全雌鲤群体首先，我们发现无论遗传性别型为XX还是XY，其cyp17a1 缺失鲤个体性腺均发育为精巢，并能正常产精。其次，利用确定的雄性特异DNA分子标记，筛选到cyp17a1 -/- XX伪雄个体，其具有正常的精巢发育和精子发生。将全雌群体和对照组雌雄混合群体各500 尾进行同塘生长对比养殖，至8 月龄或12 月龄时随机抽样检测，发现cyp17a1杂合突变雌鲤体重比同塘性别混养对照组分别高6.60%或32.66%

关键词： 鲤     两性异形     生长     cyp17a1     性类固醇激素     全雌群体    

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Label-free colorimetric nanosensor with improved sensitivity for Pb

Abdul Ghaffar Memon, Xiaohong Zhou, Yunpeng Xing, Ruoyu Wang, Lanhua Liu, Mohsin Khan, Miao He

《环境科学与工程前沿（英文）》 2019年 第13卷 第1期 doi: 10.1007/s11783-019-1094-7

摘要：

• Unmodified-AuNP based, colorimetric nanosensor was constructed for Pb2+ detection.

• 5-nucleotide truncation in DNAzyme made complete substrate detachment upon Pb2+.

• Ultrasensitive and selective detection of Lead (II) was achieved with 0.2×10-9 mol/L LOD.

关键词： Colorimetric nanosensor     Truncated 8–17 DNAzyme     Pb2+ detection     Unmodified AuNPs    

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Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

《化学科学与工程前沿（英文）》 2016年 第10卷 第1期   页码 1-15 doi: 10.1007/s11705-016-1562-6

摘要： Natural products and their derivatives represent a rich source for the discovery and development of new cancer therapeutic drugs. Bioactive components derived from natural sources including marine compounds have been shown to be effective agents in the clinic or in preclinical settings. In the present review, we present a story of discovery, synthesis and evaluation of three synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs as cancer therapeutic agents. Chemical synthesis of these compounds (BA-TPQ, TBA-TPQ, and TCBA-TPQ) has been accomplished and the mechanisms of action (MOA) and structure-activity relationships (SAR) have been investigated. In the past, the complexity of chemical synthesis and the lack of well-defined MOA have dampened the enthusiasm for the development of some makaluvamines. Recent discovery of novel molecular targets for these alkaloids (unrelated to inhibition of Topoisomerase II) warrant further consideration as clinical candidates in the future. In addition to the establishment of novel synthetic approaches and demonstration of and anticancer activities, we have successfully demonstrated that these makaluvamines attack several key molecular targets, including the MDM2-p53 pathway, providing ample opportunities of modulating the compound structure based on SAR and the use of such compounds in combination therapy in the future.

关键词： synthesis     marine drugs     tricyclic pyrroloquinone alkaloid     cancer therapy     MDM2     p53    

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标题 作者 时间 类型 操作

Effect of biochar amendment on soil’s retention capacity for estrogenic hormones from poultry manure treatment

Sukhjot MANN, Zhiming QI, Shiv O. PRASHER, Lanhai LI, Dongwei GUI, Qianjing JIANG

期刊论文

Removal of 17β-estradiol in laccase catalyzed treatment processes

XIA Qing,KONG Deyang,LIU Guoqiang,HUANG Qingguo,ALALEWI Aamr,LU Junhe

期刊论文

Primary hypertrophic osteoarthropathy: an update

null

期刊论文

17–26.5 GHz 42.5 dBm宽带高效率GaN功率放大器设计

黎明1,2,李智群1,3,郑权2,蔺兰峰2,陶洪琪2

期刊论文

Th17 Cells in autoimmune diseases

null

期刊论文

Relationship between Th17 cells and allograft rejection

Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,

期刊论文

sources of dissolved organic matter from wastewater treatment plants and their mediation effect on 17α-ethinylestradiol

期刊论文

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

null

期刊论文

Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th

Michela CIGOLA,Yibing FANG

期刊论文

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression

Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang

期刊论文

Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

Guizhen Wang, Qun Zhao, Hui Zhang, Fan Liang, Chen Zhang, Jun Wang, Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou

期刊论文

基于实时CT扫描技术的CO2和N2交替注入条件下煤吸附膨胀和解吸收缩规律研究

Ranjith, Herbert E. Huppert

期刊论文

利用cyp17a1缺失的伪雄鲤成功构建全雌鲤群体

翟刚, 舒婷婷, 陈贶新, 娄气永, 贾景怡, 黄建飞, 石闯 , 金霞, 贺江燕, 姜冬火, 钱雪桥, 胡炜, 殷战

期刊论文

Label-free colorimetric nanosensor with improved sensitivity for Pb

Abdul Ghaffar Memon, Xiaohong Zhou, Yunpeng Xing, Ruoyu Wang, Lanhua Liu, Mohsin Khan, Miao He

期刊论文

Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wei Wang,Bhavitavya Nijampatnam,Sadanandan E. Velu,Ruiwen Zhang

期刊论文